March 8, 2003

DNA Software Director of Research, Dr. Svetlana Morosyuk to Present "Oligonucleotide Hybridization: Scientific Principles and Software" at Profiling PCR and Beyond

Ann Arbor, Mich. – March 8, 2003 — Dr. Svetlana Morosyuk, DNA Sofware director of research, will present DNA Software’s scientific and software advancements as they relate to gene quantification at Cambridge Healthtech’s “Profiling PCR and Beyond” in Baltimore, Maryland.

Dr. Morosyuk will present DNA Software’s latest version of in silico environment, Visual OMP™, that is useful for designing gene quantification assays involving PCR, DNA probes, and microarrays. Visual OMP™ uses a comprehensive model of nucleic acid thermodynamics and includes algorithms for calculating the concentration of all species in an assay at any temperature. Visual OMP™ also includes the ability to predict an outcome of a single-target PCR reaction. This useful feature accounts for suboptimal primer binding, target folding, and 3’ extendibility of non-desired structures, which may occur during PCR. It allows users to explore the effects of different ingredient concentrations and annealing temperatures. The software can also be used to design and simulate PCR reactions in the presence of probe(s) and multiple primer pairs.

Dr. Morosyuk will speak at 3:30 pm, Thursday, June 5.

About DNA Software, Inc.
DNA Software, Inc. combines science and software to enable industrial genomics through advances in technologies based on nucleic acids. The company’s first software platform, OMP™ (Oligonucleotide Modeling Platform™) models in silico the folding and hybridization of single-stranded nucleic acids with great accuracy. The company combines OMP™ with scientific consulting, custom software development, and custom laboratory research to deliver state-of-the-art support for designing and developing of nucleic acid based technologies.

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“We find it [Visual OMP™] makes very accurate and sometimes surprising (but true) predictions about binding efficiency in multiplexes...” David Whitcombe, Chief Scientific Officer, DxS Ltd, UK.
“It [Visual OMP™] is very powerful software when used for multiplexing design...” Chris Novak, Ambion
“I have designed over 10,000 PCR assays in my experience with DNA Software’s Visual OMP™ and found greater than 95% success rate when using it to design my assays compared to less than 20% success without it.” Dr. Eric Bruening, MolecularMD
“I have been using DNA [Software™] for a long time, at least 8 years. I want to have the best tools available and that is why we use it.” Dr. Nancy Schoenbrunner, Roche Molecular Systems
“I am a long-term user of Visual OMP™. I like this program very much because it provides a solid scientific basis for oligo design and cuts the development time by more than half.” Olga Budker, longtime Visual OMP user
“In my experience, DNA Software™ saved me 75% of my oligo costs.” Helen Minnis, Wave 80
“DNA [Software™] has passed my tests. I’ve recommended it [Visual OMP™]. It performs extremely well.” Dr. Ned Sekinger, Luminex Corporation
“Learning to use the program [Visual OMP™] is time well spent, and the support staff at DNA Software is always ready and able to help” Dr. Sue J. Kohlhepp, Providence Portland Medical Center.